Le Meridien St. Louis Clayton is where the creative minded, the culture seekers and those who live to savor the moment unlock the destination of St. Louis. With 268 thoughtfully designed hotel rooms and 17,000 square feet of stylish event space, we guide our guests through the nuances of what makes this city great. Located in the epicenter of the chic Clayton business district, minutes from Forest Park and downtown Saint Louis, this Clayton hotel celebrates art through an effortless blend of simplicity and comfort with style and detail.